Glutathione Transferase (GST)-Activated Prodrugs

نویسندگان

  • Paolo Ruzza
  • Andrea Calderan
چکیده

Glutathione transferase (formerly GST) catalyzes the inactivation of various electrophile-producing anticancer agents via conjugation to the tripeptide glutathione. Moreover, several data link the overexpression of some GSTs, in particular GSTP1-1, to both natural and acquired resistance to various structurally unrelated anticancer drugs. Tumor overexpression of these proteins has provided a rationale for the search of GST inhibitors and GST activated cytotoxic prodrugs. In the present review we discuss the current structural and pharmacological knowledge of GST-activated cytotoxic compounds.

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عنوان ژورنال:

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2013